Injectible weight-loss drugs such as Ozempic can be life-changing for patients who have struggled to lose weight, yet some people have reported side-effects. According to Dr. Ross Perry,  medical director of Cosmedics Skin Clinics, now “Ozempic feet” is “emerging as another potential side-effect gaining attention. “Much like the face, the feet can experience sagging, wrinkling, and a loss of the usual taut, smooth appearance due to a significant reduction in body fat. In more extreme cases, particularly in individuals who were previously overweight, this can even result in excess skin or folds developing around the feet,” he said.

Taking Ozempic has even been linked with a change in shoe size, “either because of the reduced fat volume or shifting bone structure once the cushioning is lost,” Dr. Tijion Esho, an aesthetic doctor and the founder of Cultskin, told The Standard. “Shoes that once fit snugly now feel loose or uncomfortable, which can further impact posture and gait.” According to Esho, Ozempic can cause changes in the feet due to weight loss, leading to a “sudden loss of fat padding in the soles”. The fat padding in our feet cushions and absorbs impact when we walk. “When that volume suddenly disappears, it can feel like you’re walking on bone,” he said. “Patients report soreness, burning, and even difficulty standing for long periods.”

Source: Arielle Domb, MSN [4/15/25]